Daniel R. Goldstein’s (Professor of Internal Medicine and Immunobiology)
As a physician-scientist and transplant immunologist, I examine how the innate immune system, in particular Toll-like receptors, impact alloimmunity and transplant tolerance. My work as a board certified transplant cardiologist affords me insights into whether preclinical immunological studies are relevant to solid organ transplantation. In addition, my research involves studies on how aging impacts innate immunity and the role of aging on alloimmmunity. In particular, my laboratory has discovered new pathways by which aging alters inflammation during acute viral infections, atherosclerosis, and information that age-induced inflammatory responses impact the tempo of acute allograft rejection and transplant tolerance.